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Insight Horizon Media

What is functional fibrinogen?

Author

Michael Henderson

Published Mar 05, 2026

What is functional fibrinogen?

The Functional Fibrinogen assay is a rapid whole blood test which measures the fibrinogen that actually contributes to the structure and strength of the clot. Platelet function is blocked by a potent inhibitor and the resulting MA-FF reflects the fibrin component of the clot.

How do you interpret TEG results?

If we interpret our TEG values:

  1. R time 20.0 => well above the upper limit of normal (10.0 minutes) = significantly prolonged time for clot formation.
  2. K time 13.2 => normal: up to 10.0 = prolonged fibrin cross-linking.
  3. a-angle 16.5 => normal >53.0 = limited clot formation.

What is the difference between TEG and Rotem?

In fact the main difference between TEG and ROTEM is the bit which rotates (TEG rotates the cup, and ROTEM rotates the pin). Irrespective of which bit is rotating, some impediment to the rotation develops as the blood clots.

What is FLEV in TEG?

Specifically, TEG estimates the functional fibrinogen level (FLEV), by extrapolation from the MA (maximal amplitude) fibrinogen value. The MA value of a platelet-free plasma clot is proportionate to the functional fibrinogen concentration.

What is TEG trauma?

TEG is a bedside test that is useful in the setting of ‘controlled’ hemorrhage, such as liver transplant and cardiac surgery. In trauma, bleeding can occur at such a pace that the TEG result may lag behind the clinical situation, leading to delayed and inappropriate therapy.

What does a TEG show?

TEG is a non-invasive test that quantitatively measures the ability of whole blood to form a clot. The principle of this in vitro test is to detect and quantify dynamic changes of the viscoelastic properties of a blood sample during clotting under low shear stress.

How do you treat TEG?

If a coagulopathy is identified, the TEG results will point to the specific therapy to treat it, whether using fresh frozen plasma, cryoprecipitate, or an anti-fibrinolytic or thrombolytic drug.

What does Rotem test for?

BACKGROUND: ROTEM is a method of measuring hemostasis quality via the viscoelastic properties of a blood clot and is designed for patient blood management. ROTEM provides a rapid assessment of clot development from secondary hemostasis to clot lysis by evaluating clot formation, clot firmness, and clot fibrinolysis.

How does Rotem work?

ROTEM provides a global assessment of hemostasis by using a whole blood sample to demonstrate how platelets, coagulation factors, RBCS, and other elements are working together to 1) initiate a clot, 2) determine clot strength, and 3) investigate if there is any fibrinolysis.

When should I get TEG?

A heparinase TEG is used to assess for heparin-associated anticoagulation as the cause of hemorrhage. It is used most commonly following cardiopulmonary bypass procedures where heparin is reversed using protamine intraoperatively.

Why is a TEG test done?

What is TEG medical?