How does penicillin G treat syphilis?
John Castro
Published Feb 11, 2026
How does penicillin G treat syphilis?
There are no home remedies or over-the-counter drugs that will cure syphilis, but syphilis is easy to cure in its early stages. A single intramuscular injection of long acting Benzathine penicillin G (2.4 million units administered intramuscularly) will cure a person who has primary, secondary or early latent syphilis.
How long does benzathine take to cure syphilis?
Late Syphilis in Adults and Adolescents The interval between consecutive doses of benzathine penicillin should not exceed 14 days. Benzathine penicillin G 2.4 million units intramuscularly once weekly for 3 consecutive weeks is preferred over procaine penicillin 1.2 million units once daily for 20 days.
How many shots of penicillin do you need for syphilis?
Syphilis can be treated with penicillin. The penicillin is given as a shot. If you had syphilis for less than one year, you only need to get one shot. If you had syphilis for more than one year, you need three shots—one shot a week for three weeks.
How long does it take for penicillin to cure syphilis?
More serious cases that affect the brain are usually treated with daily penicillin injections given into your buttocks or a vein for 2 weeks, or a 28 day course of antibiotic tablets if you can’t have penicillin. Follow-up blood tests will be recommended once treatment finishes to check that it has worked.
What is the best treatment for syphilis?
When diagnosed and treated in its early stages, syphilis is easy to cure. The preferred treatment at all stages is penicillin, an antibiotic medication that can kill the organism that causes syphilis. If you’re allergic to penicillin, your doctor may suggest another antibiotic or recommend penicillin desensitization.
Can 1g of azithromycin cure syphilis?
Azithromycin therapy (1-g single dose) will result in fewer cases of early syphilis among exposed partners, provided that the drug’s efficacy is at least 87%. Conclusions: Azithromycin is a cost-effective alternative treatment for incubating syphilis in settings where standard intramuscular therapy is not practical.
How long does it take for benzathine penicillin to work?
Following intramuscular administration, benzylpenicillin benzathine is absorbed slowly and converted by hydrolysis to benzylpenicillin. Peak plasma levels are reached 24 hours (children) or 48 hours (adults) post-injection.
How long does benzathine penicillin G stay in your system?
Intramuscular administration of 300,000 units of penicillin G benzathine in adults results in blood levels of 0.03 to 0.05 units per mL, which are maintained for 4 to 5 days.
Can you fully recover from syphilis?
Can syphilis be cured? Yes, syphilis can be cured with the right antibiotics from your health care provider. However, treatment might not undo any damage that the infection has already done.
What medicine can cure syphilis fast?
If diagnosed and treated early, syphilis is easily curable. If you’ve been infected for less than a year, a single injection of penicillin G benzathine can halt the progression of syphilis.
Can garlic treat syphilis?
Garlic, in particular, has anti-bacterial properties that can help relieve the symptoms of syphilis.
Which antibiotic is best for syphilis?
When diagnosed and treated in its early stages, syphilis is easy to cure. The preferred treatment at all stages is penicillin, an antibiotic medication that can kill the organism that causes syphilis.
How to administer penicillin G?
Penicillin G procaine (aqueous) is for intramuscular injection only. Administer by DEEP INTRAMUSCULAR INJECTION in the upper, outer quadrant of the buttock. In neonates, infants and small children, the midlateral aspect of the thigh may be preferable. When doses are repeated, vary the injection site.