Can a transcutaneous bilirubin nomogram predict neonatal hyperbilirubinemia?
Michael Henderson
Published Feb 19, 2026
Can a transcutaneous bilirubin nomogram predict neonatal hyperbilirubinemia?
Transcutaneous bilirubin nomogram for prediction of significant neonatal hyperbilirubinemia We provide a predictive TcB tool that could allow for a noninvasive, risk-based approach to neonatal hyperbilirubinemia. We provide a predictive TcB tool that could allow for a noninvasive, risk-based approach to neonatal hyperbilirubinemia.
How is hyperhyperbilirubinemia treated in term newborns?
Hyperbilirubinemia is one of the most common problems encountered in term newborns. Historically, management guidelines were derived from studies on bilirubin toxicity in infants with hemolytic disease. More recent recommendations support the use of less intensive therapy in healthy term newborns with jaundice.
What is a high risk zone for hyperbilirubinemia?
At 48 hours, the high-risk zone had 90% sensitivity and a positive LR of 12.1, whereas the low-risk zone had 98.8% sensitivity and a negative LR of 0.02. In our study population, the probability of significant hyperbilirubinemia would be >35% for values in the high-risk zone and <0.5% for values in the low-risk zone of the nomogram.
When is phototherapy indicated in the treatment of bilirubin deficiency?
Phototherapy should be instituted when the total serum bilirubin level is at or above 15 mg per dL (257 mol per L) in infants 25 to 48 hours old, 18 mg per dL (308 mol per L) in infants 49 to 72 hours old, and 20 mg per dL (342 mol per L) in infants older than 72 hours.